Title : New treatment of muscle contracture and joint contracture through muscle regeneration with mitochondrial dynamics
Abstract:
A muscle contracture refers to a shortening of muscle length due to a decrease in the number of sarcomeres in series along the myofibrils, accompanied by an increase in the resistance to passive stretch. Joint contracture, defined as the limitation in the passive range of motion of a mobile joint, can be classified as noninflammatory diseases of the musculoskeletal system. The contractures are often a symptom of a wide variety of heterogeneous disorders that are in many cases multifactorial. Among them, the pathological changes of muscle tissue caused by immobilization-induced joint contracture include disuse skeletal muscle atrophy and skeletal muscle tissue fibrosis. Elucidating whether the cause of the limited ROM is due to spasticity alone or the secondary effects of muscle contracture can be very important. This review showed that muscle contracture and joint contracture are dramatically improved through muscle regeneration with mitochondrial dynamics.
