Title : New treatment of sarcopenia through muscle regeneration with mitochondrial dynamics
Abstract:
Sarcopenia is a common age-related skeletal muscle disorder featuring the loss of muscle mass and function. In regard to tissue repair in the human body, scientists always consider the use of stem cells. In skeletal muscle, satellite cells (SCs) are adult stem cells that maintain tissue homeostasis and repair damaged regions after injury to preserve skeletal muscle integrity. In skeletal muscle, satellite cells (SCs) are adult stem cells that maintain tissue homeostasis and repair damaged regions after injury to preserve skeletal muscle integrity. To date, considerable progress has been achieved in understanding the complex associations between stem cells in muscle and the occurrence and treatment of sarcopenia. One of the areas of recent attention is the activation and regeneration of muscle stem cells to enhance the regeneration of old muscles. Evidence demonstrates the superior regenerative capacity of myogenic stem cells from human muscles to form new muscles after the muscles have been injured. The fundamental role of satellite cells in the homeostasis of normal aging muscles and the development of endogenous regeneration in old muscles is still questionable in modern medicine, but in this review, mitochondrial dynamics activates quiescent muscle stem cells to show rapid recovery of sarcopenia through muscle regeneration.
