Title : Exploring the frontiers of regenerative medicine: Insights from systematic reviews on exosomes, PRP, polynucleotides, and stem cells
Abstract:
Regenerative medicine is rapidly evolving, offering promising therapeutic aesthetics and joint regeneration solutions. Our cohort's systematic reviews have critically examined hundreds of clinical trials of the efficacy, standardisation, scientific robustness, and ethical dimensions of multiple biologically regenerative treatments. This presentation provides a comprehensive overview of findings from existing clinical trials, shedding light on the complexities of their application and implications for clinical practice.
Through an in-depth analysis of trial methodologies and outcomes, we evaluated the translational impact of these therapies on patient care. Exosomes have the potential to regenerate cells without using cells, while PRP's effectiveness depends on how it is prepared and patient-dependent characteristics. Polynucleotides emerge as an underexplored yet promising agent, particularly in soft tissue remodelling. Although extensively studied, stem cells raise ethical concerns surrounding sourcing, characterisation, clinical justification, and variability in reported outcomes.
By critically appraising trial designs, reporting standards, and ethical adherence, our findings highlight gaps in current research, including inconsistent outcome measurements and limited long-term data. We also discuss the ethical challenges of these emerging therapies, emphasising the need for harmonised guidelines to balance innovation with patient safety and access.
This presentation invites attendees to explore the current landscape of biologics in regenerative medicine, offering valuable insights for clinicians, researchers, and policymakers. It aims to inspire a collaborative effort towards evidence-based practices and ethically sound innovation in this transformative field.
