Title : The Wolff’s law and the physiology of bone modeling in normal and post-fracture
Abstract:
Introduction: This article explores the historical evolution of understanding the impact of physiological loads on bone architecture and regeneration, from antiquity to Julius Wolff’s pioneering work, which led to the formulation of Wolff’s law. It highlights the principle that bones remodel and adapt to mechanical stress and functional demands, playing a vital role in bone physiology, healing, and disease. Wolff’s law extends beyond bones to muscles and other tissues, explaining phenomena such as stress fractures, osteoporosis from inactivity (e.g., in astronauts or bedridden patients), and adaptations in athletes under excessive load. Its relevance spans traumatology, orthopedics, sports, space medicine, and regenerative medicine.
Conclusion: In conclusion this article explores the historical development and modern significance of Wolff’s Law in bone formation and regeneration after fractures. Tracing its origins to antiquity and emphasizing Julius Wolff’s pioneering contributions, it highlights the core principle of bone remodeling in response to mechanical stress. The study emphasizes the critical importance of applying Wolff’s Law in orthopedic practice, particularly in the treatment of fractures and the monitoring of their healing processes. As a fundamental concept, Wolff’s Law demonstrates the ability of bones to adapt to mechanical forces, enabling orthopedic surgeons to optimize fracture management by considering the specific mechanical factors that influence healing and recovery.
Keywords: Wolff's law, bone, bone structure, load on bone, fractures, healing (regeneration), modeling and remodeling of bone, piezoelectric effect, orthopedics, traumatology.
