Title : Evaluating the efficacy of intra-articular analgesic cocktail for postoperative pain in total knee replacement: A comparative study across three tertiary care centers
Abstract:
Background: Effective postoperative pain management is crucial in total knee replacement (TKR) surgeries. This observational study explores the impact of an intra-articular analgesic cocktail, introduced three months into the study, on pain reduction and range of motion (ROM) post-TKR in three tertiary care centers.
Methods: The study involved 103 patients undergoing primary TKR for primary osteoarthritis across three tertiary care centers. Patients were observed in a comparative setting, with one group receiving a periarticular cocktail injection (intervention group) and the other receiving conventional treatment (control group). The Visual Analog Scale was used to assess postoperative pain at 6 hours, 24 hours, 1 week, and 1 month. ROM was measured at 24 hours, 1 week, and 1 month. Pain score analysis was conducted using the Mann-Whitney U test, while ROM evaluation employed the unpaired Student’s t-test.
Results: The sample had a mean age of 63.0 ± 8.79 years, with a male-to-female ratio of 1:5, reflecting a predominantly female cohort. The intervention group exhibited a significant reduction in pain scores at 6 hours post-surgery (p=0.003) but no significant differences at 24 hours (p=0.270) and 1 week (p=0.238). ROM at 24 hours and 1 week showed no significant difference; however, there was a significant improvement in ROM in the intervention group at 1 month (p=0.015).
Conclusions: The introduction of an intra-articular analgesic cocktail in TKR surgeries at three tertiary care centers significantly reduced immediate postoperative pain at 6 hours and enhanced ROM at 1 month. These findings underscore the potential of this approach in improving early postoperative outcomes in TKR patients.
What will audience learn from your presentation?
1. Effectiveness of Intra-Articular Analgesic Cocktails in TKR: Gain insights into the efficacy of intra-articular analgesic cocktails for managing postoperative pain in total knee replacement surgeries and how it compares with conventional treatments.
2. Improvements in Postoperative Recovery and Patient Care: Understand how the analgesic cocktail can enhance recovery, particularly in terms of immediate postoperative pain relief and intermediate-term range of motion, offering practical solutions for better patient care.
3. Implications for Future Research and Clinical Practice: Learn how the findings can guide future research directions in orthopedic surgery and pain management, and how they offer evidence-based practices that surgeons and medical practitioners can incorporate into their clinical protocols.
4. Gender-Specific Considerations in Orthopedic Surgery: Discover the potential impact of gender on the outcomes of TKR surgeries, based on the study's predominantly female cohort, which could be crucial for personalized patient care.
