Connective tissue diseases (CTDs) are a group of disorders characterized by abnormal immune system activity affecting the connective tissues throughout the body. These tissues include tendons, ligaments, skin, joints, and organs. Common CTDs include rheumatoid arthritis, systemic lupus erythematosus, and scleroderma. In CTDs, the immune system mistakenly attacks healthy tissues, leading to inflammation and tissue damage. Symptoms vary widely and may involve joint pain, skin rashes, fatigue, and internal organ complications. Treatment aims to manage symptoms and control inflammation, typically utilizing medications such as corticosteroids, disease-modifying antirheumatic drugs (DMARDs), and immunosuppressants. Multidisciplinary care involving rheumatologists, dermatologists, and other specialists is crucial for comprehensive management. Early detection and intervention play a key role in improving outcomes and enhancing the quality of life for individuals affected by connective tissue diseases.