Gout is a form of inflammatory arthritis characterized by sudden and severe attacks of pain, redness, and swelling, primarily affecting the joints. It is caused by the accumulation of uric acid crystals in the joints and tissues. Uric acid, a byproduct of the breakdown of purines found in certain foods and the body's cells, forms needle-like crystals that trigger inflammation and intense pain, commonly affecting the big toe. Factors such as genetics, diet, obesity, and certain medical conditions contribute to elevated uric acid levels. Gout attacks can be triggered by alcohol consumption, purine-rich foods, and dehydration. Over time, recurrent gout attacks may lead to joint damage and deformities. Treatment involves medications to alleviate pain and inflammation, lifestyle modifications such as dietary changes, weight management, and medications to lower uric acid levels. Managing gout effectively requires a holistic approach to prevent recurrent attacks and long-term joint damage.
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W S El Masri, Keele University, United Kingdom
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Matthew B Werd, American Academy of Podiatric Sports Medicine (AAPSM), United States
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