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4th Edition of

World Orthopedics Conference

September 24-26, 2026 | London, UK

Hypophosphatasia

Hypophosphatasia

Hypophosphatasia (HPP) is a rare genetic disorder characterized by a deficiency of the enzyme alkaline phosphatase (ALP), leading to impaired mineralization of bones and teeth. This condition results in skeletal abnormalities and can manifest across a spectrum of severity. Common features of HPP include rickets in infants, causing soft and bowed bones, and the premature loss of teeth. In severe cases, individuals may experience respiratory complications due to chest deformities. In milder forms, symptoms might be limited to dental issues or fractures later in life. HPP is caused by mutations in the ALPL gene, leading to reduced ALP activity. Diagnosis involves clinical evaluation, genetic testing, and biochemical assessments. Treatment approaches aim to manage symptoms and may include enzyme replacement therapy, supportive care, and addressing complications like fractures or dental problems. Due to its rarity and variable presentation, HPP requires a multidisciplinary approach involving geneticists, endocrinologists, orthopaedic specialists, and dentists for comprehensive management and support for affected individuals and their families.

Committee Members
Speaker at World Orthopedics Conference 2026 - Stephen S Tower

Stephen S Tower

University of Alaska Anchorage, United States
Speaker at World Orthopedics Conference 2026 - Ali Al Kaissi

Ali Al Kaissi

National Ilizarov Medical Research Center for Traumatology and Orthopaedics, Russian Federation
Ortho 2026 Speakers
Speaker at World Orthopedics Conference 2026 - Hussein Jaber

Hussein Jaber

University of Cambridge, United Kingdom
Speaker at World Orthopedics Conference 2026 - Jack Russek

Jack Russek

Touro University California, United States

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