Marble Bone Disease, clinically known as osteopetrosis, is a rare genetic disorder characterized by increased bone density and abnormal bone structure. This condition hinders proper bone remodeling, leading to bones becoming dense and brittle, resembling marble. Osteopetrosis results from mutations affecting the function of osteoclasts, the cells responsible for breaking down and reshaping bone tissue. Individuals with marble bone disease may experience skeletal abnormalities, such as fractures, deformities, and stunted growth. Additionally, the increased bone mass can interfere with bone marrow function, causing anemia and other hematological issues. Cranial nerve compression may occur, impacting vision, hearing, and facial nerve function. Treatment approaches for marble bone disease focus on managing symptoms and complications. Bone marrow transplantation may be considered in severe cases. Ongoing research aims to understand the genetic basis of osteopetrosis and develop targeted therapies to address the underlying causes of this rare and challenging condition.