Marble Bone Disease, clinically known as osteopetrosis, is a rare genetic disorder characterized by increased bone density and abnormal bone structure. This condition hinders proper bone remodeling, leading to bones becoming dense and brittle, resembling marble. Osteopetrosis results from mutations affecting the function of osteoclasts, the cells responsible for breaking down and reshaping bone tissue. Individuals with marble bone disease may experience skeletal abnormalities, such as fractures, deformities, and stunted growth. Additionally, the increased bone mass can interfere with bone marrow function, causing anemia and other hematological issues. Cranial nerve compression may occur, impacting vision, hearing, and facial nerve function. Treatment approaches for marble bone disease focus on managing symptoms and complications. Bone marrow transplantation may be considered in severe cases. Ongoing research aims to understand the genetic basis of osteopetrosis and develop targeted therapies to address the underlying causes of this rare and challenging condition.
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Stephen S Tower, University of Alaska Anchorage, United States
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Diana Hodgins, Dynamic Metrics Ltd, United Kingdom
Title : Selective denervation for persistent knee pain after total knee arthroplasty: Long-term outcomes
Shaomin Shi, Medical College of Wisconsin, United States
Title : The etiological diagnosis of torticollis
Ali Al Kaissi, Ilizarov Institute, Austria
Title : Acute Traumatic Spinal Cord Injuries(TSCI) – Is the current standard of care evidence based?
W S El Masri, Keele University, United Kingdom
Title : AI-Driven infrared imaging and telerobotics in orthopedics: Enhancing diagnostics, surgical precision, and postoperative care
Marcos Brioschi, American Academy of Thermology, United States