Any condition of the bones and joints is known as osteoarthropathy. Clubbing and periostitis of the small hand joints, particularly the distal interphalangeal and metacarpophalangeal joints, are symptoms of hypertrophic osteoarthropathy. Long bone distal extension, as well as painful, swollen joints and synovial villous proliferation, are common. The disorder can emerge on its own (primary) or as a result of other diseases, such as lung cancer. It is most commonly related with adenocarcinoma and least commonly with small cell lung cancer in patients with lung cancer. Clubbing and accelerated bone deposition on long bones are common in these patients. Their only symptoms are clubbing and painful ankles in some cases. Hypertrophic osteoarthropathy is one of many cancer-related distant effects, with lung cancer being the most common cause but also ovarian and adrenal cancers. A distant effect condition, also known as a paraneoplastic syndrome, affects distant locations and is therefore unrelated to the tumor's local compression or blockage effects. Hypercalcemia, SIADH, Cushing's syndrome, and a range of neurological problems are among the other paraneoplastic syndromes.