The Semitendinosus is one of the three muscles that make up the hamstring group, situated at the back of the thigh. In orthopaedics, this muscle is vital for hip and knee joint function. Originating from the ischial tuberosity, it runs down the back of the thigh and inserts into the upper part of the tibia. Orthopedic assessments frequently involve evaluating the semitendinosus in cases of hamstring injuries, strains, or knee-related conditions. This muscle contributes to knee flexion and hip extension, playing a crucial role in activities such as running, jumping, and deceleration. Hamstring injuries, including strains or tears of the semitendinosus, are common in sports and activities requiring sudden bursts of speed or changes in direction. Orthopedic interventions may include physical therapy, rest, and strengthening exercises to facilitate optimal healing and prevent re-injury. Understanding the anatomy and function of the semitendinosus muscle is essential in orthopaedics for diagnosing and managing conditions related to the hamstring complex, optimizing lower limb biomechanics, and facilitating effective rehabilitation after injuries.