Systemic lupus Erythematosus (SLE) is a chronic autoimmune disease characterized by the immune system mistakenly attacking healthy tissues throughout the body. This condition can affect various organs, including the skin, joints, kidneys, heart, lungs, brain, and blood cells. SLE often presents with a diverse range of symptoms, such as joint pain, skin rashes, fatigue, and fever, making it challenging to diagnose. The exact cause of SLE is unknown, but it is believed to involve a complex interplay of genetic, environmental, and hormonal factors. Women, particularly those of childbearing age, are more commonly affected. Diagnosis relies on a combination of clinical evaluation, laboratory tests, and imaging studies. Management of SLE involves a multidisciplinary approach, including medications to control inflammation and immune response, lifestyle modifications, and regular medical monitoring. While there is no cure, advancements in treatment have significantly improved the prognosis for individuals with SLE, allowing many to lead fulfilling lives with proper management.